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ea0081p390 | Endocrine-Related Cancer | ECE2022

Uncovering the immune profile in well-differentiated gastroenteropancreatic neuroendocrine tumors

Sesti Franz , Puliani Giulia , Sciarra Francesca , Feola Tiziana , Centello Roberta , Di Vito Valentina , Pandozzi Carla , Lenzi Andrea , Isidori Andrea , Venneri Mary Anna , Faggiano Antongiulio , Giannetta Elisa

Introduction: Immune tumor microenvironment plays a key role in tumors growth and metastatic spread, while its role in the heterogeneous field of neuroendocrine neoplasms (NENs) remains unclear. There is evidence that tumor progression in NENs is promoted by an immunosuppressed microenvironment created by a plethora of infiltrating immune cells. Changes in circulating leukocyte and peripheral blood mononuclear cell (PBMC) subpopulations can mirror the local alteration of...

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ea0090p423 | Pituitary and Neuroendocrinology | ECE2023

Immune profile in acromegalic patients and the impact of the current medical treatment. Resultsfrom the PROMISE study

Feola Tiziana , De Alcubierre Dario , Sada Valentina , Puliani Giulia , Sciarra Francesca , Cozzolino Alessia , Appetecchia Marialuisa , Sbardella Emilia , Jaffrain-Rea Marie-Lise , Anna Venneri Mary , Isidori Andrea

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...

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Endocrine Abstracts

Uncovering the immune profile in well-differentiated gastroenteropancreatic neuroendocrine tumors

Immune profile in acromegalic patients and the impact of the current medical treatment. Resultsfrom the PROMISE study

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